Perfil Nutricional e Qualidade de Vida em Pacientes Adultos com Doença do Enxerto Contra o Hospedeiro Crônica, no Pós Transplante de Células-Tronco Hematopoiéticas Tardio: Um Estudo Observacional

Abstract

Abstract

Introduction: Graft-versus-host disease (GVHD) is a complication of allogeneic hematopoietic stem cell transplantation, considered the main cause of morbidity and mortality, and can affect the quality of life and functionality. Objective: To evaluate the nutritional profile and quality of life of adult patients with chronic GVHD (cGVHD). Methodology: Observational study with adult patients of both genders with cGVHD. A nutritional assessment was carried out using questionnaires, anthropometric assessments, and dietary assessments. We used the Student’s T test and the Mann-Whitney test to compare variables between sexes, the chi-square test to evaluate the association between categorical variables, and Spearman’s linear correlation (p<0.05). Results: Of the 32 participants, 75% were male with a mean age of 41.3 ± 11.9 years. 56,2% were identified as overweight and 25% as malnourished. An association was observed between physical activity and degree of cGVHD (p=0.04), moderate and directly proportional correlations between nutritional profile and quality of life with a significant difference (r = 0.54 e p<0.01) and moderate and inversely proportional between muscular strength and limitation (r = -0.36) with a significant difference (p = 0.04). We found an average intake of 1761.6 ± 783.1 kcal/day and 91.15 ± 43g/day of proteins, an adequacy of 69.5% ± 31.6% and 68% ± 30.2% of the recommended amount, respectively. Conclusion: The low energy and protein intake, nutritional status, degree, and organs affected by cGVHD highlight the importance of specialized nutritional intervention to improve the quality of life of these patients.

Keywords: hematopoietic stem cell transplantation; nutritional status; quality of life; eating; recommended dietary allowances.