Use of a synthesis inhibitor of prostaglandins in cattle recipients with or without difficult of cervical manipulation

Abstract

The aim of this study was to determine the effect of flunixin meglumine on conception rate of bovine embryo recipients with or without difficulty of implementation of the cervix at inovulation. The superovulation and synchronization of donors and recipients were done for this purpose. The recipients were divided into four groups according to difficulty or not for cervical implementation and being treated or not with flunixin meglumine. Thus, experimental groups were named: Not treated with flunixin meglumine and without difficulty of cervical implementation (S/FM-CF, n=184), not treated with flunixin meglumine and with difficulty of cervical implementation (S/FM-CD, n=58), treated with flunixin meglumine and without difficulty of cervical implementation (C/FM-CF, n=38), and treated with flunixin meglumine and with difficulty of cervical implementation (C/FM-CD, n=57). The recipients treated with flunixin meglumine received an application of 500mg flunixin meglumine im (DESFLAN, Ouro Fino, Sao Paulo, Brazil) immediately after the inovulations, while the animals untreated received the application of 10mL of saline solution im. The conception rates average was 51.93%, since the conception rates of the groups S/FM-CF, S/FM-CD, C/FM-CF and C/FM-CD were, respectively, 54.35, 36.21, 50.00 and 61.40%. These results demonstrated a conception rate significantly lower (P=0.007) for recipients from the group S/FM-CD. The results showed that the use of the flunixin meglumine can be helpful in recipients with difficult of implementation of the cervix, providing the control of the phenomenon of early luteal regression.