Potencial Terapêutico de Biofilmes de Alginato e Nanopartículas de Cobre para Cicatrização de Feridas
DOI:
https://doi.org/10.9771/cp.v18i4.61207Palavras-chave:
Alginato, Cicatrização de feridas, Cobre, Nanopartículas.Resumo
A cicatrização de feridas envolve a ação de diferentes tecidos e substâncias produzidas pelo organismo. O investimento em novos dispositivos cicatrizantes melhorou a prática clínica, mas ainda há necessidade de avanços e melhorias dos curativos considerando a complexidade do controle da cicatrização de feridas e o alto custo dos produtos existentes. Os revestimentos poliméricos contendo substâncias ativas tornam-se alternativas ao tratamento de feridas cutâneas. O alginato de sódio tem sido utilizado com essa proposta devido as seguintes características: facilidade de formação de filmes, hidrogéis, fios; biocompatibilidade; degradabilidade. O alginato pode ser combinado com outros polímeros ou elementos metálicos para melhorar suas propriedades. O cobre nanoparticulado é uma boa opção para formação de nanocompósitos com alginato, pois implementa novas capacidades ao sistema de revestimento, como efeitos bactericida, hemostático e indutivo na produção de biomoléculas essenciais ao processo de regeneração tecidual. A prospecção aborda patentes publicadas nos últimos anos com foco nos efeitos biológicos dos curativos de alginato com outros polímeros e nanopartículas de cobre, bem como métodos de síntese, ensaios, resultados e aplicações de matrizes poliméricas de alginato para cicatrização de feridas.
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Referências
ALEKSANDROVNA, B.; ALEKSANDROVNA, R.; NIKOLAEVNA, O. Preparation fastening wound healing. [S.l.: s.n.], 2012.
ALIZADEH, S. et al. Copper nanoparticles promote rapid wound healing in acute full thickness defect via acceleration of skin cell migration, proliferation, and neovascularization. Biochemical and Biophysical Research Communications, v. 517, n. 4, p. 684-690, 2019. Disponível em: https://www.sciencedirect.com/science/article/pii/S0006291X19314780. Acesso em: 25 ago. 2025.
ARMSTRONG, D. G. et al. Diabetic Foot Ulcers: A Review. JAMA, v. 330, n. 1, p. 62-75, 3 jul. 2023. DOI: https://doi.org/10.1001/jama.2023.10578.
BADHE, R. V. et al. Development and characterization of conducting-polymer-based hydrogel dressing for wound healing. Turkish Journal of Pharmaceutical Sciences, v. 18, n. 4, p. 483-491, 2021.
BARROWS, T. Hydrogel Tattoo Protection and Aftercare System. [S.l.: s.n.], 2014.
BERGONZI, C. et al. Alginate/human elastin-like polypeptide composite films with antioxidant properties for potential wound healing application. International Journal of Biological Macromolecules, v. 164, p. 586-596, 2020. Disponível em: https://www.sciencedirect.com/science/article/pii/S0141813020338381. Acesso em: 25 ago. 2025.
BINGLIN, L.; YING, Z.; YAO, L. Alginate-carboxymethyl cellulose gel sponge as well as preparation method and application thereof. [S.l.: s.n.], 2020.
CAO, Y. et al. A review on the synthesis and development of alginate hydrogels for wound therapy. Journal of Materials Chemistry B, v. 11, n. 13, p. 2801-2829, 2023. DOI: http://dx.doi.org/10.1039/D2TB02808E.
CHALITANGKOON, J.; WONGKITTISIN, M.; MONVISADE, P. Silver loaded hydroxyethylacryl chitosan/sodium alginate hydrogel films for controlled drug release wound dressings. International journal of biological macromolecules, v. 159, p. 194-203, set. 2020. DOI: https://doi.org/10.1016/j.ijbiomac.2020.05.061.
CHEN, X. A kind of high strength and the novel polysaccharide cellulose medical adhesive promoting wound healing and preparation method thereof. [S.l.: s.n.], 2016.
CHENGRONG, X. et al. Liquid dressing and preparation method thereof. [S.l.: s.n.], 2021.
CHUNG, M. L. et al. Risk factors for pressure ulcers in adult patients: A meta-analysis on sociodemographic factors and the Braden scale. Journal of Clinical Nursing, v. 32, n. 9-10, p. 1979-1992, 1º maio 2023. DOI: https://doi.org/10.1111/jocn.16260.
CHUNMEI, L. Preparation method of polylactic acid-based suture line. [S.l.: s.n.], 2016.
CIBING, H.; GUIFANG, Z.; ZHIXIN, S. A kind of preparation method of active biological film tissue mending material. [S.l.: s.n.], 2018.
DEL BONO, A.; DEL BONO, C.; FERRARI, G. Hydrosoluble Film Having Healing Activity. [S.l.: s.n.], 2014.
DENG, H. et al. Mechanisms of diabetic foot ulceration: A review. Journal of Diabetes, v. 15, n. 4, p. 299-312, 1º abr. 2023. DOI: https://doi.org/10.1111/1753-0407.13372.
DENG, Z. et al. Injectable biomimetic hydrogels encapsulating Gold/metal-organic frameworks nanocomposites for enhanced antibacterial and wound healing activity under visible light actuation. Chemical Engineering Journal, v. 420, p. 129668, 2021. Disponível em: https://www.sciencedirect.com/science/article/pii/S1385894721012547. Acesso em: dia, mês e ano.
DENGYONG, H. et al. Collagen-chitosan electrostatic spinning membrane composite alginate anti-seawater soaking application and preparation method thereof. CN111481731A. 2020.
DENGYONG, H. et al. Collagen-chitosan electrostatic spinning membrane composite alginate anti-seawater soaking application and preparation method thereof. [S.l.: s.n.], 2019.
DILIPAN, E.; KAMALA, K.; SIVAPERUMAL, P. Preparation of hydrogel film with wound healing properties derived from seaweed Sargassum wightii. [S.l.: s.n.], 2022.
EVGENEVNA, G. I.; VITALEVICH, Z. I. Bio-polymer-based bandage for prophylaxis and treatment of infections for burns, trophic ulcers, and soft tissue necrosis. [S.l.: s.n.], 2018.
FANGYIN, D. et al. A kind of class aquogel type compound film dressing and preparation method thereof based on alginate. [S.l.: s.n.], 2019.
FIORENTINI, F. et al. Plant-based biocomposite films as potential antibacterial patches for skin wound healing. European Polymer Journal, v. 150, p. 110414, 2021. Disponível em: https://www.sciencedirect.com/science/article/pii/S0014305721001488. Acesso em: 25 ago. 2025.
FREEDMAN, B. R. et al. Breakthrough treatments for accelerated wound healing. Science Advances, v. 9, n. 20, p. eade7007, 23 abr. 2024. DOI: https://doi.org/10.1126/sciadv.ade7007.
GANGBIAO, J.; TIAN, H.; JINWEN, L. Natural polymer-based supramolecular self-healing hydrogel as well as preparation method and application thereof. [S.l.: s.n.], 2020.
GAO, Z. et al. Antibacterial and hemostatic bilayered electrospun nanofibrous wound dressings based on quaternized silicone and quaternized chitosan for wound healing. European Polymer Journal, v. 159, p. 110733, 2021. Disponível em: https://www.sciencedirect.com/science/article/pii/S0014305721004675. Acesso em: 25 ago. 2025.
GIZ, A. S. et al. A detailed investigation of the effect of calcium crosslinking and glycerol plasticizing on the physical properties of alginate films. International Journal of Biological Macromolecules, v. 148, p. 49-55, 2020. Disponível em: https://www.sciencedirect.com/science/article/pii/S0141813019378870. Acesso em: 25 ago. 2025.
GONG, C. P.; LUO, Y.; PAN, Y. Y. Novel synthesized zinc oxide nanoparticles loaded alginate-chitosan biofilm to enhanced wound site activity and anti-septic abilities for the management of complicated abdominal wound dehiscence. Journal of Photochemistry and Photobiology B: Biology, v. 192, p. 124-130, 2019. Disponível em: https://www.sciencedirect.com/science/article/pii/S1011134418314167. Acesso em: 25 ago. 2025.
HUI, Gan et al. Compound hemostatic plaster of nanometer multilayer. [S.l.: s.n.], 2016.
JIANHUA, L. Wound surface plaster and preparation method thereof. [S.l.: s.n.], 2022.
JIAWEI, Z.; SHENG, Z.; ANLI, W. Antibacterial hemagglutination-stopping rubber powder and preparation method thereof. [S.l.: s.n.], 2022.
KANG, L.; HAITAO, X. A kind of novel functional foam combine dressing. [S.l.: s.n.], 2018.
KANG, L.; JINTAO, C.; HAITAO, X. A kind of preparation method of the alginate Wound dressing with fibrin ferment. [S.l.: s.n.], 2017.
KARIMI KHORRAMI, N. et al. Fabrication and characterization of alginate-based films functionalized with nanostructured lipid carriers. International Journal of Biological Macromolecules, v. 182, p. 373-384, 2021. Disponível em: https://www.sciencedirect.com/science/article/pii/S0141813021007005. Acesso em: 25 ago. 2025.
KREITSBERG, G. N. et al. Biopolymer-based dressing. RU2704623C1. 2019.
KRZYSZCZYK, P. et al. The role of macrophages in acute and chronic wound healing and interventions to promote pro-wound healing phenotypes Frontiers in Physiology. Frontiers Media S.A., 1º maio 2018.
KUHLMANN, M. et al. Wound healing characteristics of a novel wound healing ointment in an abrasive wound model: A randomised, intra-individual clinical investigation. Wound Medicine, v. 24, n. 1, p. 24-32, 2019. Disponível em: https://www.sciencedirect.com/science/article/pii/S2213909518300624. Acesso em: 25 ago. 2025.
LI, L. et al. Preparation method of nano-silver-containing sodium alginate based antibacterial medical dressing. CN103446621B. 2013.
LI, Q.; LIU, K.; JIANG, T.; REN, S.; KANG, Y.; LI, W.; YAO, H.; YANG, X.; DAI, H.; CHEN, Z. Injectable and self-healing chitosan-based hydrogel with MOF-loaded α-lipoic acid promotes diabetic wound healing. Materials Science and Engineering: C, v. 131, p. 112519, 2021.
LIANG, W. et al. Biomedical dressing with antibacterial, anti-inflammatory and wound healing promoting functions and preparation method thereof. [S.l.: s.n.], 2020.
NIKOLAEVICH, K. G.; GEORGIEVNA, K. O.; EVGENEVNA, G. I. Biopolymer-based dressing. [S.l.: s.n.], 2019.
QINGTAO, W. Natural high-polymer material adhesive bandage. [S.l.: s.n.], 2017.
QINMEI, W.; YUBING, H. Multiple-crosslinking injectable hydrogel and preparation method and application thereof. [S.l.: s.n.], 2021.
RAGUVARAN, R. et al. Sodium alginate and gum acacia hydrogels of ZnO nanoparticles show wound healing effect on fibroblast cells. International Journal of Biological Macromolecules, v. 96, p. 185-191, 2017. Disponível em: https://www.sciencedirect.com/science/article/pii/S0141813016315604. Acesso em: 25 ago. 2025.
RENLI, Z.; YI, Y.; CHENGFENG, L. Alginate-based hydrogel dressing and preparation method thereof Abstract. [S.l.: s.n.], 2016.
SARDO, P. M. G. et al. A systematic review of prevalence and incidence of pressure ulcers/injuries in hospital emergency services. Journal of Tissue Viability, v. 32, n. 2, p. 179-187, 2023. Disponível em: https://www.sciencedirect.com/science/article/pii/S0965206X23000128. Acesso em: 25 ago. 2025.
SHASHA, L.; YI, Y.; CHENGFENG, Li. Oral ulcer membrane and preparation method thereof. [S.l.: s.n.], 2016.
SHIBING, H. et al. Sodium alginate spray and production process thereof. [S.l.: s.n.], 2014.
THOMAS, D. et al. Alginate film modified with aloevera gel and cellulose nanocrystals for wound dressing application: Preparation, characterization and in vitro evaluation. Journal of Drug Delivery Science and Technology, v. 59, p. 101894, 2020. Disponível em: https://www.sciencedirect.com/science/article/pii/S1773224720311837. Acesso em: dia, mês e ano.
WANG, L. et al. N-carboxymethyl chitosan/sodium alginate composite hydrogel loading plasmid DNA as a promising gene activated matrix for in-situ burn wound treatment. Bioactive Materials, v. 15, p. 330-342, 2022a. Disponível em: https://www.sciencedirect.com/science/article/pii/S2452199X21005843. Acesso em: 25 ago. 2025.
WANG, M. et al. Engineering functional natural polymer-based nanocomposite hydrogels for wound healing Nanoscale Advances. Royal Society of Chemistry, 17 nov. 2022b.
WANG, P. et al. Enzyme hybrid virus-like hollow mesoporous CuO adhesive hydrogel spray through glucose-activated cascade reaction to efficiently promote diabetic wound healing. Chemical Engineering Journal, v. 415, p. 128901, 2021. Disponível em: https://www.sciencedirect.com/science/article/pii/S1385894721004952. Acesso em: dia, mês e ano.
WOOK, Y. J.; HO, L. J. in situ Hydrogel Forming Powder Composition for Wound Healing, and Method for Preparing thereof. [S.l.: s.n.], 2018.
XIAODAN, Z.; JINAN, J. A kind of biological antibacterial film forming liquid medical dressing and preparation method thereof. [S.l.: s.n.], 2016.
YANAGI, K.; ITO, S. Wound healing film for in vivo tissue, adhesive film in vivo, porous spherical bone repairing particles, and self-curable bone repairing paste. [S.l.: s.n.], 2014.
YUNG-PIN, L. Alginate monomer structure with metal crystallite embedded, alginate salt structure with metal crystallite embedded, and method of producing alginate hydrogel. [S.l.: s.n.], 2014.
ZAMANI, S. et al. Assessing the efficacy of curcumin-loaded alginate hydrogel on skin wound healing: A gene expression analysis. Journal of Biomaterials Applications, v. 38, n. 9, p. 957-974, 7 mar. 2024. DOI: https://doi.org/10.1177/08853282241238581.
ZHANG, M.; ZHAO, X. Alginate hydrogel dressings for advanced wound management. International Journal of Biological Macromolecules, v. 162, p. 1414-1428, 2020. Disponível em: https://www.sciencedirect.com/science/article/pii/S0141813020340708. Acesso em: 25 ago. 2025.
ZHENGNAN, Z.; LITAO, H.; NINGJIAN, A. A kind of alginate dressing for treating bedsore and preparation method thereof. [S.l.: s.n.], 2015.
ZHENGNAN, Z. et al. A kind of anthocyanidin alginate dressing. [S.l.: s.n.], 2019.
ZHENYONG, M. A kind of medical dressing promoting wound healing. [S.l.: s.n.], 2019.
ZULING, Z.; JINLING, Y.; SHIDAN, L. A kind of obstetrics and gynecology department quick hemostatic dressing and preparation method thereof. [S.l.: s.n.], 2018.
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